WoWDB

Blizzard: "For all your NOPE needs!"

The first time the player is introduced to the trinket is as a quest item for Nope, and later in the daily Nope Nope Nope.

The established method of dealing with 'nopes' is to burn them with fire. Lots of fire.  If you want more specific info (along with some hilarious .GIFs), check out this article at KnowYourMeme.