WoWDB

Requires Death Knight

Engrave your weapon with a rune that gives your ghoul's attacks a chance to apply one of the following debuffs to the target, Death: Healing Reduction, War: Increases damage taken from the Death Knight, Famine: Reduces damage dealt to the Death Knight, Pestilence: Slows the target and deals damage over time.

Modifying your rune requires a Runeforge in Ebon Hold.